Predicting the physiological relevance of in vitro cancer preventive activities of phytochemicals.

2.50
Hdl Handle:
http://hdl.handle.net/10146/17400
Title:
Predicting the physiological relevance of in vitro cancer preventive activities of phytochemicals.
Authors:
Howells, Lynne M.; Moiseeva, Elena P.; Neal, Christopher P.; Foreman, Bethany E.; Andreadi, Catherine K.; Sun, Yi-yang; Hudson, E. Ann; Manson, Margaret M
Abstract:
There is growing interest in the ability of phytochemicals to prevent chronic diseases, such as cancer and heart disease. However, some of these agents have poor bioavailability and many of the in-depth studies into their mechanisms of action have been carried out in vitro using doses which are unachievable in humans. In order to optimize the design of chemopreventive treatment, it is important to determine which of the many reported mechanisms of action are clinically relevant. In this review we consider the physiologically achievable doses for a few of the best studied agents (indole-3-carbinol, diindolylmethane, curcumin, epigallocatechin-3-gallate and resveratrol) and summarize the data derived from studies using these low concentrations in cell culture. We then cite examples of in vitro effects which have been observed in vivo. Finally, the ability of agent combinations to act synergistically or antagonistically is considered. We conclude that each of the compounds shows an encouraging range of activities in vitro at concentrations which are likely to be physiologically relevant. There are also many examples of in vivo studies which validate in vitro observations. An important consideration is that combinations of agents can result in significant activity at concentrations where any single agent is inactive. Thus, for each of the compounds reviewed here, in vitro studies have provided useful insights into their mechanisms of action in humans. However, data are lacking on the full range of activities at low doses in vitro and the benefits or otherwise of combinations in vivo.
Citation:
Acta Pharmacol Sin. 2007 28(9):1274-1304
Journal:
Acta Pharmacologica Sinica
Issue Date:
2007
URI:
http://hdl.handle.net/10146/17400
DOI:
10.1111/j.1745-7254.2007.00690.x
Additional Links:
http://www.chinaphar.com/1671-4083/28/1274.htm; http://www.blackwell-synergy.com/servlet/useragent?func=synergy&synergyAction=showTOC&journalCode=aphs&volume=28&issue=9&year=2007%02%22=null
Type:
Article
Language:
en
ISSN:
16714083; 17457254
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorHowells, Lynne M.-
dc.contributor.authorMoiseeva, Elena P.-
dc.contributor.authorNeal, Christopher P.-
dc.contributor.authorForeman, Bethany E.-
dc.contributor.authorAndreadi, Catherine K.-
dc.contributor.authorSun, Yi-yang-
dc.contributor.authorHudson, E. Ann-
dc.contributor.authorManson, Margaret M-
dc.date.accessioned2008-02-04T10:28:32Z-
dc.date.available2008-02-04T10:28:32Z-
dc.date.issued2007-
dc.identifier.citationActa Pharmacol Sin. 2007 28(9):1274-1304en
dc.identifier.issn16714083-
dc.identifier.issn17457254-
dc.identifier.doi10.1111/j.1745-7254.2007.00690.x-
dc.identifier.urihttp://hdl.handle.net/10146/17400-
dc.description.abstractThere is growing interest in the ability of phytochemicals to prevent chronic diseases, such as cancer and heart disease. However, some of these agents have poor bioavailability and many of the in-depth studies into their mechanisms of action have been carried out in vitro using doses which are unachievable in humans. In order to optimize the design of chemopreventive treatment, it is important to determine which of the many reported mechanisms of action are clinically relevant. In this review we consider the physiologically achievable doses for a few of the best studied agents (indole-3-carbinol, diindolylmethane, curcumin, epigallocatechin-3-gallate and resveratrol) and summarize the data derived from studies using these low concentrations in cell culture. We then cite examples of in vitro effects which have been observed in vivo. Finally, the ability of agent combinations to act synergistically or antagonistically is considered. We conclude that each of the compounds shows an encouraging range of activities in vitro at concentrations which are likely to be physiologically relevant. There are also many examples of in vivo studies which validate in vitro observations. An important consideration is that combinations of agents can result in significant activity at concentrations where any single agent is inactive. Thus, for each of the compounds reviewed here, in vitro studies have provided useful insights into their mechanisms of action in humans. However, data are lacking on the full range of activities at low doses in vitro and the benefits or otherwise of combinations in vivo.en
dc.language.isoenen
dc.relation.urlhttp://www.chinaphar.com/1671-4083/28/1274.htmen
dc.relation.urlhttp://www.blackwell-synergy.com/servlet/useragent?func=synergy&synergyAction=showTOC&journalCode=aphs&volume=28&issue=9&year=2007%02%22=nullen
dc.subjectbioavailabilityen
dc.subjectcancer chemopreventionen
dc.subjectcurcuminen
dc.subjectdieten
dc.subjectdiindolylmethaneen
dc.subjectepigallo-catechin-3-gallateen
dc.subjectindole-3-carbinolen
dc.subjectresveratrolen
dc.subject.meshAnimalsen
dc.subject.meshAntineoplastic Agents, Phytogenicen
dc.subject.meshAntineoplastic Combined Chemotherapy Protocolsen
dc.subject.meshCatechinen
dc.subject.meshCurcuminen
dc.subject.meshHumansen
dc.subject.meshIndolesen
dc.subject.meshNeoplasmsen
dc.titlePredicting the physiological relevance of in vitro cancer preventive activities of phytochemicals.en
dc.typeArticleen
dc.identifier.journalActa Pharmacologica Sinicaen
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