State of validation of biomarkers of carcinogen exposure and early effects and their applicability to molecular epidemiology.

2.50
Hdl Handle:
http://hdl.handle.net/10146/15223
Title:
State of validation of biomarkers of carcinogen exposure and early effects and their applicability to molecular epidemiology.
Abstract:
By providing objective measures of exposure to specific agents and early, biologically relevant effects, at the level of the individual, biomarkers can provide a way of investigating associations between exposure and disease. For their potential to be realised, it is essential that biomarkers undergo the critical process of validation. Biomarker validation encompasses two different levels: firstly, the analytical and operational methodology; and secondly the inherent ability of biomarkers to reflect the chemical nature, level and duration of an individual's exposure and/or the degree of disease risk. The current Report focuses on the second aspect, summarising the state of validation of the most important biomarkers of exposure to food-related carcinogens or their early effects and identifying the gaps in knowledge that remain.
Citation:
State of validation of biomarkers of carcinogen exposure and early effects and their applicability to molecular epidemiology. Ed. Peter B. Farmer, Soterios A. Kyrtopoulos, Jean M. Emeny. 2007.
Publisher:
The Nofer Institute of Occupational Medicine
Issue Date:
2007
URI:
http://hdl.handle.net/10146/15223
Additional Links:
http://www.ecnis.org/index.php?option=com_content&task=view&id=628&Itemid=135
Type:
Book
Language:
en
Series/Report no.:
ECNIS Report; 4
ISBN:
978-83-60818-06-0
Sponsors:
ECNIS is a Network of Excellence within the European Union Sixth Framework Programme, Priority 5: Food Quality and Safety. It brings together some of the best European research groups in a concerted effort to achieve improved understanding of the environmental causes of cancer, of the potential of diet to prevent cancer and of the ways by which heredity can affect individual susceptibility to carcinogens, with the ultimate aim of reducing the cancer burden in Europe. ECNIS is coordinated by Prof. Konrad Rydzyƒski, The Nofer Institute of Occupational Medicine, Sw. Teresy 8, 91-348 Lodz, Poland. This report has been prepared as part of ECNIS Work Package 6: Development and Validation of Biomarkers of Exposure and of Bioindicators of Disease for Use in Epidemiology.
Appears in Collections:
Reports

Full metadata record

DC FieldValue Language
dc.date.accessioned2007-12-14T10:46:10Z-
dc.date.available2007-12-14T10:46:10Z-
dc.date.issued2007-
dc.identifier.citationState of validation of biomarkers of carcinogen exposure and early effects and their applicability to molecular epidemiology. Ed. Peter B. Farmer, Soterios A. Kyrtopoulos, Jean M. Emeny. 2007.en
dc.identifier.isbn978-83-60818-06-0-
dc.identifier.urihttp://hdl.handle.net/10146/15223-
dc.description.abstractBy providing objective measures of exposure to specific agents and early, biologically relevant effects, at the level of the individual, biomarkers can provide a way of investigating associations between exposure and disease. For their potential to be realised, it is essential that biomarkers undergo the critical process of validation. Biomarker validation encompasses two different levels: firstly, the analytical and operational methodology; and secondly the inherent ability of biomarkers to reflect the chemical nature, level and duration of an individual's exposure and/or the degree of disease risk. The current Report focuses on the second aspect, summarising the state of validation of the most important biomarkers of exposure to food-related carcinogens or their early effects and identifying the gaps in knowledge that remain.en
dc.description.sponsorshipECNIS is a Network of Excellence within the European Union Sixth Framework Programme, Priority 5: Food Quality and Safety. It brings together some of the best European research groups in a concerted effort to achieve improved understanding of the environmental causes of cancer, of the potential of diet to prevent cancer and of the ways by which heredity can affect individual susceptibility to carcinogens, with the ultimate aim of reducing the cancer burden in Europe. ECNIS is coordinated by Prof. Konrad Rydzyƒski, The Nofer Institute of Occupational Medicine, Sw. Teresy 8, 91-348 Lodz, Poland. This report has been prepared as part of ECNIS Work Package 6: Development and Validation of Biomarkers of Exposure and of Bioindicators of Disease for Use in Epidemiology.en
dc.language.isoenen
dc.publisherThe Nofer Institute of Occupational Medicineen
dc.relation.ispartofseriesECNIS Reporten
dc.relation.ispartofseries4en
dc.relation.urlhttp://www.ecnis.org/index.php?option=com_content&task=view&id=628&Itemid=135en
dc.subjectbiomarkersen
dc.subjectexposureen
dc.subjectmolecular epidemiologyen
dc.titleState of validation of biomarkers of carcinogen exposure and early effects and their applicability to molecular epidemiology.en
dc.typeBooken
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