Vitamins B2 and B6 and genetic polymorphisms related to one-carbon metabolism as risk factors for gastric adenocarcinoma in the European prospective investigation into cancer and nutrition.

2.50
Hdl Handle:
http://hdl.handle.net/10146/114971
Title:
Vitamins B2 and B6 and genetic polymorphisms related to one-carbon metabolism as risk factors for gastric adenocarcinoma in the European prospective investigation into cancer and nutrition.
Authors:
Eussen, Simone J. P. M.; Vollset, Stein Emil; Hustad, Steinar; Midttun, Oivind; Meyer, Klaus; Fredriksen, Ase; Ueland, Per Magne; Jenab, Mazda; Slimani, Nadia; Ferrari, Pietro; Agudo, Antonio; Sala, Nuria; Capella, Gabriel; Del Giudice, Giuseppe; Palli, Domenico; Boeing, Heiner; Weikert, Cornelia; Bueno-de-Mesquita, H. Bas; Büchner, Frederike L.; Carneiro, Fatima; Berrino, Franco; Vineis, Paolo; Tumino, Rosario; Panico, Salvatore; Berglund, Goran; Manjer, Jonas; Stenling, Roger; Hallmans, Goran; Martínez, Carmen; Arrizola, Larraitz; Barricarte, Aurelio; Navarro, Carmen; Rodriguez, Laudina; Bingham, Sheila; Linseisen, Jakob; Kaaks, Rudolf; Overvad, Kim; Tjonneland, Anne; Peeters, Petra H. M.; Numans, Mattijs E.; Clavel-Chapelon, Francoise; Boutron-Ruault, Marie-Christine; Morois, Sophie; Trichopoulou, Antonia; Lund, Eiliv; Plebani, Mario; Riboli, Elio; Gonzalez, Carlos A.
Abstract:
B vitamins and polymorphisms in genes coding for enzymes involved in one-carbon metabolism may affect DNA synthesis and methylation and thereby be implicated in carcinogenesis. Previous data on vitamins B2 and B6 and genetic polymorphisms other than those involving MTHFR as risk factors for gastric cancer (GC) are sparse and inconsistent. In this case-control study nested within the European Prospective Investigation into Cancer and Nutrition cohort, cases (n = 235) and controls (n = 601) were matched for study center, age, sex, and time of blood sampling. B2 and B6 species were measured in plasma, and the sum of riboflavin and flavin mononucleotide was used as the main exposure variable for vitamin B2 status, whereas the sum of pyridoxal 5'-phosphate, pyridoxal, and 4-pyridoxic acid was used to define vitamin B6 status. In addition, we determined eight polymorphisms related to one-carbon metabolism. Relative risks for GC risk were calculated with conditional logistic regression, adjusted for Helicobacter pylori infection status and smoking status. Adjusted relative risks per quartile (95% confidence interval, P(trend)) were 0.85 (0.72-1.01, 0.06) for vitamin B2 and 0.78 (0.65-0.93, <0.01) for vitamin B6. Both relations were stronger in individuals with severe chronic atrophic gastritis. The polymorphisms were not associated with GC risk and did not modify the observed vitamin-cancer associations. In summary, results from this large European cohort study showed an inverse association between vitamin B2 and GC risk, which is borderline significant, and a significant inverse association between vitamin B6 and GC risk.
Citation:
Cancer Epidemiol. Biomarkers Prev. 2010, 19 (1):28-38
Journal:
Cancer Epidemiology, Biomarkers & Prevention : a publication of the American Association for Cancer Research
Issue Date:
Jan-2010
URI:
http://hdl.handle.net/10146/114971
DOI:
10.1158/1055-9965.EPI-08-1096
PubMed ID:
20056620
Additional Links:
http://cebp.aacrjournals.org/content/19/1/28.long
Type:
Article
Language:
en
ISSN:
1538-7755
Sponsors:
Some authors are partners of ECNIS, a network of excellence of the EC (6FP contract 513943).
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorEussen, Simone J. P. M.en
dc.contributor.authorVollset, Stein Emilen
dc.contributor.authorHustad, Steinaren
dc.contributor.authorMidttun, Oivinden
dc.contributor.authorMeyer, Klausen
dc.contributor.authorFredriksen, Aseen
dc.contributor.authorUeland, Per Magneen
dc.contributor.authorJenab, Mazdaen
dc.contributor.authorSlimani, Nadiaen
dc.contributor.authorFerrari, Pietroen
dc.contributor.authorAgudo, Antonioen
dc.contributor.authorSala, Nuriaen
dc.contributor.authorCapella, Gabrielen
dc.contributor.authorDel Giudice, Giuseppeen
dc.contributor.authorPalli, Domenicoen
dc.contributor.authorBoeing, Heineren
dc.contributor.authorWeikert, Corneliaen
dc.contributor.authorBueno-de-Mesquita, H. Basen
dc.contributor.authorBüchner, Frederike L.en
dc.contributor.authorCarneiro, Fatimaen
dc.contributor.authorBerrino, Francoen
dc.contributor.authorVineis, Paoloen
dc.contributor.authorTumino, Rosarioen
dc.contributor.authorPanico, Salvatoreen
dc.contributor.authorBerglund, Goranen
dc.contributor.authorManjer, Jonasen
dc.contributor.authorStenling, Rogeren
dc.contributor.authorHallmans, Goranen
dc.contributor.authorMartínez, Carmenen
dc.contributor.authorArrizola, Larraitzen
dc.contributor.authorBarricarte, Aurelioen
dc.contributor.authorNavarro, Carmenen
dc.contributor.authorRodriguez, Laudinaen
dc.contributor.authorBingham, Sheilaen
dc.contributor.authorLinseisen, Jakoben
dc.contributor.authorKaaks, Rudolfen
dc.contributor.authorOvervad, Kimen
dc.contributor.authorTjonneland, Anneen
dc.contributor.authorPeeters, Petra H. M.en
dc.contributor.authorNumans, Mattijs E.en
dc.contributor.authorClavel-Chapelon, Francoiseen
dc.contributor.authorBoutron-Ruault, Marie-Christineen
dc.contributor.authorMorois, Sophieen
dc.contributor.authorTrichopoulou, Antoniaen
dc.contributor.authorLund, Eiliven
dc.contributor.authorPlebani, Marioen
dc.contributor.authorRiboli, Elioen
dc.contributor.authorGonzalez, Carlos A.en
dc.date.accessioned2010-11-08T12:54:26Z-
dc.date.available2010-11-08T12:54:26Z-
dc.date.issued2010-01-
dc.identifier.citationCancer Epidemiol. Biomarkers Prev. 2010, 19 (1):28-38en
dc.identifier.issn1538-7755-
dc.identifier.pmid20056620-
dc.identifier.doi10.1158/1055-9965.EPI-08-1096-
dc.identifier.urihttp://hdl.handle.net/10146/114971-
dc.description.abstractB vitamins and polymorphisms in genes coding for enzymes involved in one-carbon metabolism may affect DNA synthesis and methylation and thereby be implicated in carcinogenesis. Previous data on vitamins B2 and B6 and genetic polymorphisms other than those involving MTHFR as risk factors for gastric cancer (GC) are sparse and inconsistent. In this case-control study nested within the European Prospective Investigation into Cancer and Nutrition cohort, cases (n = 235) and controls (n = 601) were matched for study center, age, sex, and time of blood sampling. B2 and B6 species were measured in plasma, and the sum of riboflavin and flavin mononucleotide was used as the main exposure variable for vitamin B2 status, whereas the sum of pyridoxal 5'-phosphate, pyridoxal, and 4-pyridoxic acid was used to define vitamin B6 status. In addition, we determined eight polymorphisms related to one-carbon metabolism. Relative risks for GC risk were calculated with conditional logistic regression, adjusted for Helicobacter pylori infection status and smoking status. Adjusted relative risks per quartile (95% confidence interval, P(trend)) were 0.85 (0.72-1.01, 0.06) for vitamin B2 and 0.78 (0.65-0.93, <0.01) for vitamin B6. Both relations were stronger in individuals with severe chronic atrophic gastritis. The polymorphisms were not associated with GC risk and did not modify the observed vitamin-cancer associations. In summary, results from this large European cohort study showed an inverse association between vitamin B2 and GC risk, which is borderline significant, and a significant inverse association between vitamin B6 and GC risk.en
dc.description.sponsorshipSome authors are partners of ECNIS, a network of excellence of the EC (6FP contract 513943).en
dc.language.isoenen
dc.relation.urlhttp://cebp.aacrjournals.org/content/19/1/28.longen
dc.subjectStomach Neoplasmsen
dc.subjectAdenocarcinomaen
dc.subjectRisk Factorsen
dc.subjectVitamin B 6en
dc.subjectRiboflavinen
dc.subjectPolymorphismen
dc.subjectGenetic Predisposition to Diseaseen
dc.subjectHumansen
dc.subjectCase-Control Studiesen
dc.subject.meshAdenocarcinoma-
dc.subject.meshCase-Control Studies-
dc.subject.meshChromatography, Liquid-
dc.subject.meshFemale-
dc.subject.meshGenetic Predisposition to Disease-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMass Spectrometry-
dc.subject.meshMiddle Aged-
dc.subject.meshOne-Carbon Group Transferases-
dc.subject.meshPolymorphism, Single Nucleotide-
dc.subject.meshRiboflavin-
dc.subject.meshRisk Factors-
dc.subject.meshStomach Neoplasms-
dc.subject.meshVitamin B 6-
dc.titleVitamins B2 and B6 and genetic polymorphisms related to one-carbon metabolism as risk factors for gastric adenocarcinoma in the European prospective investigation into cancer and nutrition.en
dc.typeArticleen
dc.identifier.journalCancer Epidemiology, Biomarkers & Prevention : a publication of the American Association for Cancer Researchen

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