Serum levels of organochlorine pesticides in healthy adults from five regions of Spain.

2.50
Hdl Handle:
http://hdl.handle.net/10146/114915
Title:
Serum levels of organochlorine pesticides in healthy adults from five regions of Spain.
Authors:
Jakszyn, Paula; Goni, Fernando; Etxeandia, Arsenio; Vives, Asuncion; Millan, Esmeralda; Lopez, Raul; Amiano, Pilar; Ardanaz, Eva; Barricarte, Aurelio; Chirlaque, M. Dolores; Dorronsoro, Miren; Larranaga, Nerea; Martinez, Carmen; Navarro, Carmen; Rodriguez, Laudina; Sanchez, M. Jose; Tormo, M. Jose; Gonzalez, Carlos A.; Agudo, Antonio
Abstract:
The aim of this study was to measure of serum levels of p,p'-dichlorodiphenyl trichloroethane (p,p'-DDT), p,p'-dichlorodiphenyl dichlorethylene (p,p'-DDE), beta-hexachlorocyclohexane (beta-HCH), and hexachlorobenzene (HCB) in healthy adults in Spain. Furthermore, we also analyzed these levels according to dietary, other lifestyle factors and anthropometric characteristics. We measured the concentrations of such organochlorine pesticides (OCPs) in serum samples collected during 1992-1996 from 953 subjects aged 35-64 years, they were residents of five Spanish regions, they were randomly selected from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. OCPs were determined by means of gas chromatography with electron-capture detection (GC-ECD). The most frequent compound found in serum was p,p'-DDE, present in 98% of the samples, followed by HCB and beta-HCH, found in 89% and 77% of samples, respectively, while p,p'-DDT could be measured only in 26% of subjects. The geometric means of serum concentrations (ng/g lipid) were 822 for p,p'-DDE, 167 for beta-HCH, and 379 for HCB. The concentrations of all OCPs were positively associated with age and body mass index, and decreased along the period of blood collection. No association was found between OCPs levels and dietary factors. The concentrations of p,p'-DDE and beta-HCB were higher in Murcia, one of southern regions, most likely associated with intensive past use of pesticides related to agricultural practices, while higher levels of HCB were found in Navarra, located in the north, maybe due to industrial use rather than agricultural application.
Citation:
Chemosphere 2009, 76 (11):1518-1524
Journal:
Chemosphere
Issue Date:
Sep-2009
URI:
http://hdl.handle.net/10146/114915
DOI:
10.1016/j.chemosphere.2009.05.048
PubMed ID:
19586652
Additional Links:
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6V74-4WPHRD0-1&_user=1843694&_coverDate=09%2F30%2F2009&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000055040&_version=1&_urlVersion=0&_userid=1843694&md5=f3ec5e117883316aee02ccf5670b5b49&searchtype=a
Type:
Article
Language:
en
ISSN:
1879-1298
Sponsors:
Some authors (PJ, CAG, AA) are members of ECNIS (Environmental Cancer Risk, Nutrition and Individual Susceptibility), a Network of Excellence of the 6th EU Framework Programme (FP6, FOOD-CT-2005-513 943).
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorJakszyn, Paulaen
dc.contributor.authorGoni, Fernandoen
dc.contributor.authorEtxeandia, Arsenioen
dc.contributor.authorVives, Asuncionen
dc.contributor.authorMillan, Esmeraldaen
dc.contributor.authorLopez, Raulen
dc.contributor.authorAmiano, Pilaren
dc.contributor.authorArdanaz, Evaen
dc.contributor.authorBarricarte, Aurelioen
dc.contributor.authorChirlaque, M. Doloresen
dc.contributor.authorDorronsoro, Mirenen
dc.contributor.authorLarranaga, Nereaen
dc.contributor.authorMartinez, Carmenen
dc.contributor.authorNavarro, Carmenen
dc.contributor.authorRodriguez, Laudinaen
dc.contributor.authorSanchez, M. Joseen
dc.contributor.authorTormo, M. Joseen
dc.contributor.authorGonzalez, Carlos A.en
dc.contributor.authorAgudo, Antonioen
dc.date.accessioned2010-11-08T10:00:24Z-
dc.date.available2010-11-08T10:00:24Z-
dc.date.issued2009-09-
dc.identifier.citationChemosphere 2009, 76 (11):1518-1524en
dc.identifier.issn1879-1298-
dc.identifier.pmid19586652-
dc.identifier.doi10.1016/j.chemosphere.2009.05.048-
dc.identifier.urihttp://hdl.handle.net/10146/114915-
dc.description.abstractThe aim of this study was to measure of serum levels of p,p'-dichlorodiphenyl trichloroethane (p,p'-DDT), p,p'-dichlorodiphenyl dichlorethylene (p,p'-DDE), beta-hexachlorocyclohexane (beta-HCH), and hexachlorobenzene (HCB) in healthy adults in Spain. Furthermore, we also analyzed these levels according to dietary, other lifestyle factors and anthropometric characteristics. We measured the concentrations of such organochlorine pesticides (OCPs) in serum samples collected during 1992-1996 from 953 subjects aged 35-64 years, they were residents of five Spanish regions, they were randomly selected from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. OCPs were determined by means of gas chromatography with electron-capture detection (GC-ECD). The most frequent compound found in serum was p,p'-DDE, present in 98% of the samples, followed by HCB and beta-HCH, found in 89% and 77% of samples, respectively, while p,p'-DDT could be measured only in 26% of subjects. The geometric means of serum concentrations (ng/g lipid) were 822 for p,p'-DDE, 167 for beta-HCH, and 379 for HCB. The concentrations of all OCPs were positively associated with age and body mass index, and decreased along the period of blood collection. No association was found between OCPs levels and dietary factors. The concentrations of p,p'-DDE and beta-HCB were higher in Murcia, one of southern regions, most likely associated with intensive past use of pesticides related to agricultural practices, while higher levels of HCB were found in Navarra, located in the north, maybe due to industrial use rather than agricultural application.en
dc.description.sponsorshipSome authors (PJ, CAG, AA) are members of ECNIS (Environmental Cancer Risk, Nutrition and Individual Susceptibility), a Network of Excellence of the 6th EU Framework Programme (FP6, FOOD-CT-2005-513 943).en
dc.language.isoenen
dc.relation.urlhttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6V74-4WPHRD0-1&_user=1843694&_coverDate=09%2F30%2F2009&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000055040&_version=1&_urlVersion=0&_userid=1843694&md5=f3ec5e117883316aee02ccf5670b5b49&searchtype=aen
dc.subjectPesticidesen
dc.subjectHydrocarbons, Chlorinateden
dc.subjectHexachlorobenzeneen
dc.subjectDichlorodiphenyl Dichloroethyleneen
dc.subjectLindaneen
dc.subjectDDTen
dc.subjectEnvironmental Pollutantsen
dc.subjectEnvironmental Exposureen
dc.subjectEnvironmental Monitoringen
dc.subjectHumansen
dc.subjectBlooden
dc.subjectCohort Studiesen
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshCohort Studies-
dc.subject.meshDDT-
dc.subject.meshDemography-
dc.subject.meshDichlorodiphenyl Dichloroethylene-
dc.subject.meshDiet-
dc.subject.meshEating-
dc.subject.meshEnvironmental Exposure-
dc.subject.meshEnvironmental Monitoring-
dc.subject.meshEnvironmental Pollutants-
dc.subject.meshFemale-
dc.subject.meshHexachlorobenzene-
dc.subject.meshHumans-
dc.subject.meshHydrocarbons, Chlorinated-
dc.subject.meshLife Style-
dc.subject.meshLindane-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshPesticides-
dc.subject.meshSpain-
dc.titleSerum levels of organochlorine pesticides in healthy adults from five regions of Spain.en
dc.typeArticleen
dc.identifier.journalChemosphereen

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