Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: findings from the international consortium of bladder cancer.

2.50
Hdl Handle:
http://hdl.handle.net/10146/114785
Title:
Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: findings from the international consortium of bladder cancer.
Authors:
Stern, Mariana C.; Lin, Jie; Figueroa, Jonine D.; Kelsey, Karl T.; Kiltie, Anne E.; Yuan, Jian-Min; Matullo, Giuseppe; Fletcher, Tony; Benhamou, Simone; Taylor, Jack A.; Placidi, Donatella; Zhang, Zuo-Feng; Steineck, Gunnar; Rothman, Nathaniel; Kogevinas, Manolis; Silverman, Debra; Malats, Nuria; Chanock, Stephen; Wu, Xifeng; Karagas, Margaret R.; Andrew, Angeline S.; Nelson, Heather H.; Bishop, D. Timothy; Sak, Sei Chung; Choudhury, Ananya; Barrett, Jennifer H.; Elliot, Faye; Corral, Roman; Joshi, Amit D.; Gago-Dominguez, Manuela; Cortessis, Victoria K.; Xiang, Yong-Bing; Gao, Yu-Tang; Vineis, Paolo; Sacerdote, Carlotta; Guarrera, Simonetta; Polidoro, Silvia; Allione, Alessandra; Gurzau, Eugen; Koppova, Kvetoslava; Kumar, Rajiv; Rudnai, Peter; Porru, Stefano; Carta, Angela; Campagna, Marcello; Arici, Cecilia; Park, Sung Shim Lani; Garcia-Closas, Montserrat
Abstract:
Tobacco smoking is the most important and well-established bladder cancer risk factor and a rich source of chemical carcinogens and reactive oxygen species that can induce damage to DNA in urothelial cells. Therefore, common variation in DNA repair genes might modify bladder cancer risk. In this study, we present results from meta-analyses and pooled analyses conducted as part of the International Consortium of Bladder Cancer. We included data on 10 single nucleotide polymorphisms corresponding to seven DNA repair genes from 13 studies. Pooled analyses and meta-analyses included 5,282 cases and 5,954 controls of non-Latino white origin. We found evidence for weak but consistent associations with ERCC2 D312N [rs1799793; per-allele odds ratio (OR), 1.10; 95% confidence interval (95% CI), 1.01-1.19; P = 0.021], NBN E185Q (rs1805794; per-allele OR, 1.09; 95% CI, 1.01-1.18; P = 0.028), and XPC A499V (rs2228000; per-allele OR, 1.10; 95% CI, 1.00-1.21; P = 0.044). The association with NBN E185Q was limited to ever smokers (interaction P = 0.002) and was strongest for the highest levels of smoking dose and smoking duration. Overall, our study provides the strongest evidence to date for a role of common variants in DNA repair genes in bladder carcinogenesis.
Citation:
Cancer Res. 2009, 69 (17):6857-6864
Journal:
Cancer Research
Issue Date:
1-Sep-2009
URI:
http://hdl.handle.net/10146/114785
DOI:
10.1158/0008-5472.CAN-09-1091
PubMed ID:
19706757
Additional Links:
http://cancerres.aacrjournals.org/content/69/17/6857.long; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782435/?tool=pubmed
Type:
Article
Language:
en
ISSN:
1538-7445
Sponsors:
The TBCS was supported by a grant to ECNIS, a network of excellence operating within the European Union 6th Framework Program, Priority 5: ‘‘Food Quality and Safety’’ (contract no. 513943), by a grant of the Italian Association for Cancer Research, of the Piedmont Region Progetti di Ricerca Sanitaria Finalizzata, and of the Ministry of Health, Oncology Integrated Project ‘‘Cancer Primary Prevention in Italy: a research-based approach,’’ Italy.
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorStern, Mariana C.en
dc.contributor.authorLin, Jieen
dc.contributor.authorFigueroa, Jonine D.en
dc.contributor.authorKelsey, Karl T.en
dc.contributor.authorKiltie, Anne E.en
dc.contributor.authorYuan, Jian-Minen
dc.contributor.authorMatullo, Giuseppeen
dc.contributor.authorFletcher, Tonyen
dc.contributor.authorBenhamou, Simoneen
dc.contributor.authorTaylor, Jack A.en
dc.contributor.authorPlacidi, Donatellaen
dc.contributor.authorZhang, Zuo-Fengen
dc.contributor.authorSteineck, Gunnaren
dc.contributor.authorRothman, Nathanielen
dc.contributor.authorKogevinas, Manolisen
dc.contributor.authorSilverman, Debraen
dc.contributor.authorMalats, Nuriaen
dc.contributor.authorChanock, Stephenen
dc.contributor.authorWu, Xifengen
dc.contributor.authorKaragas, Margaret R.en
dc.contributor.authorAndrew, Angeline S.en
dc.contributor.authorNelson, Heather H.en
dc.contributor.authorBishop, D. Timothyen
dc.contributor.authorSak, Sei Chungen
dc.contributor.authorChoudhury, Ananyaen
dc.contributor.authorBarrett, Jennifer H.en
dc.contributor.authorElliot, Fayeen
dc.contributor.authorCorral, Romanen
dc.contributor.authorJoshi, Amit D.en
dc.contributor.authorGago-Dominguez, Manuelaen
dc.contributor.authorCortessis, Victoria K.en
dc.contributor.authorXiang, Yong-Bingen
dc.contributor.authorGao, Yu-Tangen
dc.contributor.authorVineis, Paoloen
dc.contributor.authorSacerdote, Carlottaen
dc.contributor.authorGuarrera, Simonettaen
dc.contributor.authorPolidoro, Silviaen
dc.contributor.authorAllione, Alessandraen
dc.contributor.authorGurzau, Eugenen
dc.contributor.authorKoppova, Kvetoslavaen
dc.contributor.authorKumar, Rajiven
dc.contributor.authorRudnai, Peteren
dc.contributor.authorPorru, Stefanoen
dc.contributor.authorCarta, Angelaen
dc.contributor.authorCampagna, Marcelloen
dc.contributor.authorArici, Ceciliaen
dc.contributor.authorPark, Sung Shim Lanien
dc.contributor.authorGarcia-Closas, Montserraten
dc.date.accessioned2010-11-05T10:19:09Z-
dc.date.available2010-11-05T10:19:09Z-
dc.date.issued2009-09-01-
dc.identifier.citationCancer Res. 2009, 69 (17):6857-6864en
dc.identifier.issn1538-7445-
dc.identifier.pmid19706757-
dc.identifier.doi10.1158/0008-5472.CAN-09-1091-
dc.identifier.urihttp://hdl.handle.net/10146/114785-
dc.description.abstractTobacco smoking is the most important and well-established bladder cancer risk factor and a rich source of chemical carcinogens and reactive oxygen species that can induce damage to DNA in urothelial cells. Therefore, common variation in DNA repair genes might modify bladder cancer risk. In this study, we present results from meta-analyses and pooled analyses conducted as part of the International Consortium of Bladder Cancer. We included data on 10 single nucleotide polymorphisms corresponding to seven DNA repair genes from 13 studies. Pooled analyses and meta-analyses included 5,282 cases and 5,954 controls of non-Latino white origin. We found evidence for weak but consistent associations with ERCC2 D312N [rs1799793; per-allele odds ratio (OR), 1.10; 95% confidence interval (95% CI), 1.01-1.19; P = 0.021], NBN E185Q (rs1805794; per-allele OR, 1.09; 95% CI, 1.01-1.18; P = 0.028), and XPC A499V (rs2228000; per-allele OR, 1.10; 95% CI, 1.00-1.21; P = 0.044). The association with NBN E185Q was limited to ever smokers (interaction P = 0.002) and was strongest for the highest levels of smoking dose and smoking duration. Overall, our study provides the strongest evidence to date for a role of common variants in DNA repair genes in bladder carcinogenesis.en
dc.description.sponsorshipThe TBCS was supported by a grant to ECNIS, a network of excellence operating within the European Union 6th Framework Program, Priority 5: ‘‘Food Quality and Safety’’ (contract no. 513943), by a grant of the Italian Association for Cancer Research, of the Piedmont Region Progetti di Ricerca Sanitaria Finalizzata, and of the Ministry of Health, Oncology Integrated Project ‘‘Cancer Primary Prevention in Italy: a research-based approach,’’ Italy.en
dc.language.isoenen
dc.relation.urlhttp://cancerres.aacrjournals.org/content/69/17/6857.longen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782435/?tool=pubmeden
dc.subjectUrinary Bladder Neoplasmsen
dc.subjectRisk Factorsen
dc.subjectSmokingen
dc.subjectHumansen
dc.subjectGenetic Predisposition to Diseaseen
dc.subjectPolymorphismen
dc.subjectDNA Repairen
dc.subjectEpidemiologyen
dc.subject.meshContinental Population Groups-
dc.subject.meshDNA Repair-
dc.subject.meshDNA-Binding Proteins-
dc.subject.meshFemale-
dc.subject.meshGenetic Predisposition to Disease-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshPolymorphism, Single Nucleotide-
dc.subject.meshRisk-
dc.subject.meshRisk Factors-
dc.subject.meshSmoking-
dc.subject.meshUrinary Bladder Neoplasms-
dc.subject.meshXeroderma Pigmentosum Group D Protein-
dc.titlePolymorphisms in DNA repair genes, smoking, and bladder cancer risk: findings from the international consortium of bladder cancer.en
dc.typeArticleen
dc.identifier.journalCancer Researchen

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