Prospective study of physical activity and risk of primary adenocarcinomas of the oesophagus and stomach in the EPIC (European Prospective Investigation into Cancer and nutrition) cohort.

2.50
Hdl Handle:
http://hdl.handle.net/10146/114770
Title:
Prospective study of physical activity and risk of primary adenocarcinomas of the oesophagus and stomach in the EPIC (European Prospective Investigation into Cancer and nutrition) cohort.
Authors:
Huerta, Jose Maria; Navarro, Carmen; Chirlaque, Maria-Dolores; Tormo, Maria-Jose; Steindorf, Karen; Buckland, Genevieve; Carneiro, Fatima; Johnsen, Nina Fons; Overvad, Kim; Stegger, Jakob; Tjonneland, Anne; Boutron-Ruault, Marie-Christine; Clavel-Chapelon, Francoise; Morois, Sophie; Boeing, Heiner; Kaaks, Rudolf; Rohrmann, Sabine; Vigl, Matthaus; Lagiou, Pagona; Trichopoulos, Dimitrios; Trichopoulou, Antonia; Bas Bueno-de-Mesquita, H.; Monninkhof, Evelyn M.; Numans, Mattijs E.; Peeters, Petra H.; Mattiello, Amalia; Pala, Valeria; Palli, Domenico; Tumino, Rosario; Vineis, Paolo; Agudo, Antonio; Ardanaz, Eva; Arriola, Larraitz; Molina-Montes, Esther; Rodriguez, Laudina; Lindkvist, Bjorn; Manjer, Jonas; Stenling, Roger; Lund, Eiliv; Crowe, Francesca L.; Key, Timothy J.; Khaw, Kay-Tee; Wareham, Nicholas J.; Jenab, Mazda; Norat, Teresa; Romaguera, Dora; Riboli, Elio; Gonzalez, Carlos A.
Abstract:
OBJECTIVE: To analyse the association between types of physical activity (occupational, recreational and household, vigorous and overall) and risk of primary oesophageal (OAC) or gastric adenocarcinoma (GAC). METHODS: From nine European countries, 420,449 participants were recruited between 1991 and 2000 and followed-up for a mean of 8.8 years to register incident GAC and OAC. Information on physical activity (PA), diet, lifestyle and health-related variables was obtained at baseline. Helicobacter pylori infection status was considered in a subset of 1,211 participants. Analyses were repeated by tumour site (cardia/non-cardia) and histological type (intestinal/diffuse). RESULTS: During the follow-up, 410 GAC and 80 OAC occurred. A lower risk of overall and non-cardia GAC was found for increasing levels of a PA index which combined occupational PA with weekly time spent in sports and cycling. The hazard ratio (HR) of GAC was 0.69, 95% CI: 0.50-0.94, for the comparison between active and inactive participants according to the PA index (HR = 0.44, 95% CI:0.26-0.74, for non-cardia GAC). No effect was found for cardia tumours or histological subtypes of GAC. PA of any kind was not associated with OAC. CONCLUSIONS: Overall and distal (non-cardia) gastric tumours were inversely associated with time spent on cycling and sports and a total PA index. No association was found for any type of PA and risk of cardia cancers of the stomach.
Citation:
Cancer Causes Control 2010, 21 (5):657-669
Journal:
Cancer Causes & Control : CCC
Issue Date:
May-2010
URI:
http://hdl.handle.net/10146/114770
DOI:
10.1007/s10552-009-9493-x
PubMed ID:
20052611
Additional Links:
http://www.springerlink.com/content/5n272700m7008225/
Type:
Article
Language:
en
ISSN:
1573-7225
Sponsors:
Some authors are partners of ECNIS, a network of excellence of the EC (6FP contract 513943).
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorHuerta, Jose Mariaen
dc.contributor.authorNavarro, Carmenen
dc.contributor.authorChirlaque, Maria-Doloresen
dc.contributor.authorTormo, Maria-Joseen
dc.contributor.authorSteindorf, Karenen
dc.contributor.authorBuckland, Genevieveen
dc.contributor.authorCarneiro, Fatimaen
dc.contributor.authorJohnsen, Nina Fonsen
dc.contributor.authorOvervad, Kimen
dc.contributor.authorStegger, Jakoben
dc.contributor.authorTjonneland, Anneen
dc.contributor.authorBoutron-Ruault, Marie-Christineen
dc.contributor.authorClavel-Chapelon, Francoiseen
dc.contributor.authorMorois, Sophieen
dc.contributor.authorBoeing, Heineren
dc.contributor.authorKaaks, Rudolfen
dc.contributor.authorRohrmann, Sabineen
dc.contributor.authorVigl, Matthausen
dc.contributor.authorLagiou, Pagonaen
dc.contributor.authorTrichopoulos, Dimitriosen
dc.contributor.authorTrichopoulou, Antoniaen
dc.contributor.authorBas Bueno-de-Mesquita, H.en
dc.contributor.authorMonninkhof, Evelyn M.en
dc.contributor.authorNumans, Mattijs E.en
dc.contributor.authorPeeters, Petra H.en
dc.contributor.authorMattiello, Amaliaen
dc.contributor.authorPala, Valeriaen
dc.contributor.authorPalli, Domenicoen
dc.contributor.authorTumino, Rosarioen
dc.contributor.authorVineis, Paoloen
dc.contributor.authorAgudo, Antonioen
dc.contributor.authorArdanaz, Evaen
dc.contributor.authorArriola, Larraitzen
dc.contributor.authorMolina-Montes, Estheren
dc.contributor.authorRodriguez, Laudinaen
dc.contributor.authorLindkvist, Bjornen
dc.contributor.authorManjer, Jonasen
dc.contributor.authorStenling, Rogeren
dc.contributor.authorLund, Eiliven
dc.contributor.authorCrowe, Francesca L.en
dc.contributor.authorKey, Timothy J.en
dc.contributor.authorKhaw, Kay-Teeen
dc.contributor.authorWareham, Nicholas J.en
dc.contributor.authorJenab, Mazdaen
dc.contributor.authorNorat, Teresaen
dc.contributor.authorRomaguera, Doraen
dc.contributor.authorRiboli, Elioen
dc.contributor.authorGonzalez, Carlos A.en
dc.date.accessioned2010-11-05T11:15:34Z-
dc.date.available2010-11-05T11:15:34Z-
dc.date.issued2010-05-
dc.identifier.citationCancer Causes Control 2010, 21 (5):657-669en
dc.identifier.issn1573-7225-
dc.identifier.pmid20052611-
dc.identifier.doi10.1007/s10552-009-9493-x-
dc.identifier.urihttp://hdl.handle.net/10146/114770-
dc.description.abstractOBJECTIVE: To analyse the association between types of physical activity (occupational, recreational and household, vigorous and overall) and risk of primary oesophageal (OAC) or gastric adenocarcinoma (GAC). METHODS: From nine European countries, 420,449 participants were recruited between 1991 and 2000 and followed-up for a mean of 8.8 years to register incident GAC and OAC. Information on physical activity (PA), diet, lifestyle and health-related variables was obtained at baseline. Helicobacter pylori infection status was considered in a subset of 1,211 participants. Analyses were repeated by tumour site (cardia/non-cardia) and histological type (intestinal/diffuse). RESULTS: During the follow-up, 410 GAC and 80 OAC occurred. A lower risk of overall and non-cardia GAC was found for increasing levels of a PA index which combined occupational PA with weekly time spent in sports and cycling. The hazard ratio (HR) of GAC was 0.69, 95% CI: 0.50-0.94, for the comparison between active and inactive participants according to the PA index (HR = 0.44, 95% CI:0.26-0.74, for non-cardia GAC). No effect was found for cardia tumours or histological subtypes of GAC. PA of any kind was not associated with OAC. CONCLUSIONS: Overall and distal (non-cardia) gastric tumours were inversely associated with time spent on cycling and sports and a total PA index. No association was found for any type of PA and risk of cardia cancers of the stomach.en
dc.description.sponsorshipSome authors are partners of ECNIS, a network of excellence of the EC (6FP contract 513943).en
dc.language.isoenen
dc.relation.urlhttp://www.springerlink.com/content/5n272700m7008225/en
dc.subjectEsophageal Neoplasmsen
dc.subjectStomach Neoplasmsen
dc.subjectAdenocarcinomaen
dc.subjectRisk Factorsen
dc.subjectLeisure Activitiesen
dc.subjectExerciseen
dc.subjectHealth Behavioren
dc.subjectNutrition Surveysen
dc.subjectEurope/epidemiologyen
dc.subjectProspective Studiesen
dc.subject.meshAdenocarcinoma-
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshEsophageal Neoplasms-
dc.subject.meshEurope-
dc.subject.meshExercise-
dc.subject.meshFemale-
dc.subject.meshHealth Behavior-
dc.subject.meshHumans-
dc.subject.meshIncidence-
dc.subject.meshLeisure Activities-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshNutrition Surveys-
dc.subject.meshProspective Studies-
dc.subject.meshRisk Factors-
dc.subject.meshStomach Neoplasms-
dc.titleProspective study of physical activity and risk of primary adenocarcinomas of the oesophagus and stomach in the EPIC (European Prospective Investigation into Cancer and nutrition) cohort.en
dc.typeArticleen
dc.identifier.journalCancer Causes & Control : CCCen

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