Pooled analysis of studies on DNA adducts and dietary vitamins.

2.50
Hdl Handle:
http://hdl.handle.net/10146/114769
Title:
Pooled analysis of studies on DNA adducts and dietary vitamins.
Authors:
Ragin, Camille; Minor, Aerie; Agudo, Antonio; Farmer, Peter; Garte, Seymour; Gonzales, Carlos; Kalina, Ivan; Matullo, Giuseppe; Popov, Todor; Palli, Domenico; Peluso, Marco; Ricceri, Fulvio; Sram, Radim; Vineis, Paolo; Taioli, Emanuela
Abstract:
OBJECTIVES: There is some evidence that dietary components that are rich in antioxidant and vitamins are inversely associated with DNA adduct levels induced by environmental carcinogens such as polycyclic aromatic hydrocarbons, although the epidemiologic data are inconsistent. This study addresses the association between vitamins, DNA adducts and smoking. METHODS: A combined analysis of individual data on the association between bulky DNA adducts and dietary vitamins was conducted. A Medline search was performed to identify studies on healthy subjects in which smoking and vitamins intake information were available, and bulky DNA adducts were measured in peripheral blood with 32P-postlabelling. Eight published studies met the eligibility criteria, and individual data from 7 data sets including 2758 subjects were obtained. GSTM1 and GSTT1 were also available on all the subjects. RESULTS: Vitamin E was inversely significantly associated with DNA adducts after adjustment for possible confounding factors. Vitamins A and C were not independent predictors of DNA adducts. A stratified analysis showed that vitamin A had a significant inverse association with DNA adducts in ever smokers only. CONCLUSIONS: This result is relevant to planning any future chemo-preventive interventions directed to high risk subgroups of the population, for cancer prevention.
Citation:
Mutat. Res. 2010, 705 (2):77-82
Journal:
Mutation Research
Issue Date:
Oct-2010
URI:
http://hdl.handle.net/10146/114769
DOI:
10.1016/j.mrrev.2010.04.004
PubMed ID:
20399891
Additional Links:
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T2G-4YXK0JS-2&_user=1843694&_coverDate=10%2F31%2F2010&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000055040&_version=1&_urlVersion=0&_userid=1843694&md5=5248cdac70827f61270095f01290e620&searchtype=a
Type:
Article
Language:
en
ISSN:
0027-5107
Sponsors:
This study was partially supported by grants from ‘‘Associazione Italiana per la Ricerca sul Cancro’’, and by the Environmental Cancer Risk, Nutrition and Individual Susceptibility European Union Network of Excellence (ECNIS, Contract No. FOOD-CT-2005- 513943) and a grant from NIH 5P20CA132385-03.
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorRagin, Camilleen
dc.contributor.authorMinor, Aerieen
dc.contributor.authorAgudo, Antonioen
dc.contributor.authorFarmer, Peteren
dc.contributor.authorGarte, Seymouren
dc.contributor.authorGonzales, Carlosen
dc.contributor.authorKalina, Ivanen
dc.contributor.authorMatullo, Giuseppeen
dc.contributor.authorPopov, Todoren
dc.contributor.authorPalli, Domenicoen
dc.contributor.authorPeluso, Marcoen
dc.contributor.authorRicceri, Fulvioen
dc.contributor.authorSram, Radimen
dc.contributor.authorVineis, Paoloen
dc.contributor.authorTaioli, Emanuelaen
dc.date.accessioned2010-11-05T10:56:14Z-
dc.date.available2010-11-05T10:56:14Z-
dc.date.issued2010-10-
dc.identifier.citationMutat. Res. 2010, 705 (2):77-82en
dc.identifier.issn0027-5107-
dc.identifier.pmid20399891-
dc.identifier.doi10.1016/j.mrrev.2010.04.004-
dc.identifier.urihttp://hdl.handle.net/10146/114769-
dc.description.abstractOBJECTIVES: There is some evidence that dietary components that are rich in antioxidant and vitamins are inversely associated with DNA adduct levels induced by environmental carcinogens such as polycyclic aromatic hydrocarbons, although the epidemiologic data are inconsistent. This study addresses the association between vitamins, DNA adducts and smoking. METHODS: A combined analysis of individual data on the association between bulky DNA adducts and dietary vitamins was conducted. A Medline search was performed to identify studies on healthy subjects in which smoking and vitamins intake information were available, and bulky DNA adducts were measured in peripheral blood with 32P-postlabelling. Eight published studies met the eligibility criteria, and individual data from 7 data sets including 2758 subjects were obtained. GSTM1 and GSTT1 were also available on all the subjects. RESULTS: Vitamin E was inversely significantly associated with DNA adducts after adjustment for possible confounding factors. Vitamins A and C were not independent predictors of DNA adducts. A stratified analysis showed that vitamin A had a significant inverse association with DNA adducts in ever smokers only. CONCLUSIONS: This result is relevant to planning any future chemo-preventive interventions directed to high risk subgroups of the population, for cancer prevention.en
dc.description.sponsorshipThis study was partially supported by grants from ‘‘Associazione Italiana per la Ricerca sul Cancro’’, and by the Environmental Cancer Risk, Nutrition and Individual Susceptibility European Union Network of Excellence (ECNIS, Contract No. FOOD-CT-2005- 513943) and a grant from NIH 5P20CA132385-03.en
dc.language.isoenen
dc.relation.urlhttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T2G-4YXK0JS-2&_user=1843694&_coverDate=10%2F31%2F2010&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000055040&_version=1&_urlVersion=0&_userid=1843694&md5=5248cdac70827f61270095f01290e620&searchtype=aen
dc.subjectCarcinogensen
dc.subjectPolycyclic aromatic hydrocarbonsen
dc.subjectSmokingen
dc.subjectDNA Adductsen
dc.subjectAntioxidant vitaminsen
dc.subject.meshAge Factorsen
dc.subject.meshAntioxidantsen
dc.subject.meshCarcinogensen
dc.subject.meshDNA Adductsen
dc.subject.meshDieten
dc.subject.meshEnvironmental Exposureen
dc.subject.meshHumansen
dc.subject.meshSmokingen
dc.subject.meshVitaminen
dc.titlePooled analysis of studies on DNA adducts and dietary vitamins.en
dc.typeArticleen
dc.identifier.journalMutation Researchen

Related articles on PubMed

All Items in ECNIS-NIOM are protected by copyright, with all rights reserved, unless otherwise indicated.