Polychlorinated biphenyls in Spanish adults: determinants of serum concentrations.

2.50
Hdl Handle:
http://hdl.handle.net/10146/114768
Title:
Polychlorinated biphenyls in Spanish adults: determinants of serum concentrations.
Authors:
Agudo, Antonio; Goni, Fernando; Etxeandia, Arsenio; Vives, Asuncion; Millan, Esmeralda; Lopez, Raul; Amiano, Pilar; Ardanaz, Eva; Barricarte, Aurelio; Chirlaque, M. Dolores; Dorronsoro, Miren; Jakszyn, Paula; Larranaga, Nerea; Martinez, Carmen; Navarro, Carmen; Rodriguez, Laudina; Sanchez, M. Jose; Tormo, M. Jose; Gonzalez, Carlos A.
Abstract:
BACKGROUND: Polychlorinated biphenyls (PCBs) are persistent compounds that may pose an environmental hazard to humans, food being the main source of exposure for the general population. OBJECTIVE: To measure the serum concentrations of the main PCBs in subjects from the general population in Spain, and to assess potential determinants of such concentrations. METHODS: Serum was obtained from blood samples of 953 subjects aged 35-64 years, residents in five Spanish regions (three from the North and two from the South), randomly selected from the EPIC-Spain cohort. Blood collection took place during 1992-1996 and four PCB congeners (118, 138, 153 and 180) were determined by means of gas chromatography with electron-capture detection (GC-ECD). RESULTS: The concentration of total PCBs was 459 ng/g lipids (or 3.1 microg/l); the corresponding figures for PCB 153 were 186 ng/g lipids and 1.25 microg/l. Men had higher values than women, PCB levels increased with age, and serum concentration of PCBs was higher in northern regions. Body mass index (BMI) was inversely related to PCB concentrations, and fish intake was the dietary factor showing the greatest association with serum PCBs. The pattern described was similar for each congener separately. CONCLUSIONS: We found concentrations similar to those reported in European countries where blood collection was carried during the same period. Regional differences within Spain are not fully explained by anthropometric or dietary factors. The inverse association with BMI suggests that in the mid-1990s there was still ongoing or recent exposure to PCBs in Spain.
Citation:
Environ. Res. 2009, 109 (5):620-628
Journal:
Environmental Research
Issue Date:
Jul-2009
URI:
http://hdl.handle.net/10146/114768
DOI:
10.1016/j.envres.2009.03.009
PubMed ID:
19403125
Additional Links:
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WDS-4W5M0F8-1&_user=1843694&_coverDate=07%2F31%2F2009&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000055040&_version=1&_urlVersion=0&_userid=1843694&md5=e5646f6452241f9dd392cd31ccfd7071&searchtype=a
Type:
Article
Language:
en
ISSN:
1096-0953
Sponsors:
Some authors (AA, CAG, PJ) are members of The Environmental Cancer Risk, Nutrition and Individual Susceptibility (ECNIS), a Network of Excellence of the 6th EU Framework Programme (FP6,FOOD-CT- 2005-513943).
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorAgudo, Antonioen
dc.contributor.authorGoni, Fernandoen
dc.contributor.authorEtxeandia, Arsenioen
dc.contributor.authorVives, Asuncionen
dc.contributor.authorMillan, Esmeraldaen
dc.contributor.authorLopez, Raulen
dc.contributor.authorAmiano, Pilaren
dc.contributor.authorArdanaz, Evaen
dc.contributor.authorBarricarte, Aurelioen
dc.contributor.authorChirlaque, M. Doloresen
dc.contributor.authorDorronsoro, Mirenen
dc.contributor.authorJakszyn, Paulaen
dc.contributor.authorLarranaga, Nereaen
dc.contributor.authorMartinez, Carmenen
dc.contributor.authorNavarro, Carmenen
dc.contributor.authorRodriguez, Laudinaen
dc.contributor.authorSanchez, M. Joseen
dc.contributor.authorTormo, M. Joseen
dc.contributor.authorGonzalez, Carlos A.en
dc.date.accessioned2010-11-05T09:59:33Z-
dc.date.available2010-11-05T09:59:33Z-
dc.date.issued2009-07-
dc.identifier.citationEnviron. Res. 2009, 109 (5):620-628en
dc.identifier.issn1096-0953-
dc.identifier.pmid19403125-
dc.identifier.doi10.1016/j.envres.2009.03.009-
dc.identifier.urihttp://hdl.handle.net/10146/114768-
dc.description.abstractBACKGROUND: Polychlorinated biphenyls (PCBs) are persistent compounds that may pose an environmental hazard to humans, food being the main source of exposure for the general population. OBJECTIVE: To measure the serum concentrations of the main PCBs in subjects from the general population in Spain, and to assess potential determinants of such concentrations. METHODS: Serum was obtained from blood samples of 953 subjects aged 35-64 years, residents in five Spanish regions (three from the North and two from the South), randomly selected from the EPIC-Spain cohort. Blood collection took place during 1992-1996 and four PCB congeners (118, 138, 153 and 180) were determined by means of gas chromatography with electron-capture detection (GC-ECD). RESULTS: The concentration of total PCBs was 459 ng/g lipids (or 3.1 microg/l); the corresponding figures for PCB 153 were 186 ng/g lipids and 1.25 microg/l. Men had higher values than women, PCB levels increased with age, and serum concentration of PCBs was higher in northern regions. Body mass index (BMI) was inversely related to PCB concentrations, and fish intake was the dietary factor showing the greatest association with serum PCBs. The pattern described was similar for each congener separately. CONCLUSIONS: We found concentrations similar to those reported in European countries where blood collection was carried during the same period. Regional differences within Spain are not fully explained by anthropometric or dietary factors. The inverse association with BMI suggests that in the mid-1990s there was still ongoing or recent exposure to PCBs in Spain.en
dc.description.sponsorshipSome authors (AA, CAG, PJ) are members of The Environmental Cancer Risk, Nutrition and Individual Susceptibility (ECNIS), a Network of Excellence of the 6th EU Framework Programme (FP6,FOOD-CT- 2005-513943).en
dc.language.isoenen
dc.relation.urlhttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WDS-4W5M0F8-1&_user=1843694&_coverDate=07%2F31%2F2009&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000055040&_version=1&_urlVersion=0&_userid=1843694&md5=e5646f6452241f9dd392cd31ccfd7071&searchtype=aen
dc.subjectPolychlorinated Biphenylsen
dc.subjectEnvironmental Pollutantsen
dc.subjectEnvironmental Exposureen
dc.subjectHumansen
dc.subjectBlooden
dc.subjectChromatographyen
dc.subject.meshAdult-
dc.subject.meshChromatography, Gas-
dc.subject.meshDiet-
dc.subject.meshEnvironmental Exposure-
dc.subject.meshEnvironmental Pollutants-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshLife Style-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshPolychlorinated Biphenyls-
dc.subject.meshSpain-
dc.titlePolychlorinated biphenyls in Spanish adults: determinants of serum concentrations.en
dc.typeArticleen
dc.identifier.journalEnvironmental Researchen

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