Gender-related differences in response to mutagens and carcinogens.

2.50
Hdl Handle:
http://hdl.handle.net/10146/114443
Title:
Gender-related differences in response to mutagens and carcinogens.
Authors:
Kirsch-Volders, M.; Bonassi, S.; Herceg, Z.; Hirvonen, A.; Moller, L.; Phillips, D. H.
Abstract:
The incidences of many cancers can be very different in men and women. Besides differences in exposures to putative causative agents, it is plausible that both genetic and epigenetic effects play roles in these differences. In addition, gender-specific lifestyle and behavioural factors may modulate the effects of exposure to genotoxins. This commentary focuses on several aspects of gender-related differences in responses to mutagens and carcinogens, including sensitivity to chromosome damage, the contribution of genotypic variation and the role of DNA methylation. It is concluded that the reasons for gender differences in cancer susceptibility remain largely unknown in many cases, and the subject deserves more attention and study.
Citation:
Mutagenesis 2010, 25 (3):213-221
Journal:
Mutagenesis
Issue Date:
May-2010
URI:
http://hdl.handle.net/10146/114443
DOI:
10.1093/mutage/geq008
PubMed ID:
20194421
Additional Links:
http://mutage.oxfordjournals.org/content/25/3/213.long
Type:
Article
Language:
en
ISSN:
1464-3804
Sponsors:
M. K.-V., A. H., L. M. and D. H. P. are members of the European Union Network of Excellence Environmental Cancer Risk, Nutrition and Individual Susceptibility (ECNIS, www.ecnis.org, Contract No. FOOD-CT-2005- 513943). This commentary is based on the proceedings of a symposium held at the ECNIS Annual Meeting in Leuven, Belgium, in March 2009.
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorKirsch-Volders, M.en
dc.contributor.authorBonassi, S.en
dc.contributor.authorHerceg, Z.en
dc.contributor.authorHirvonen, A.en
dc.contributor.authorMoller, L.en
dc.contributor.authorPhillips, D. H.en
dc.date.accessioned2010-11-03T12:22:38Z-
dc.date.available2010-11-03T12:22:38Z-
dc.date.issued2010-05-
dc.identifier.citationMutagenesis 2010, 25 (3):213-221en
dc.identifier.issn1464-3804-
dc.identifier.pmid20194421-
dc.identifier.doi10.1093/mutage/geq008-
dc.identifier.urihttp://hdl.handle.net/10146/114443-
dc.description.abstractThe incidences of many cancers can be very different in men and women. Besides differences in exposures to putative causative agents, it is plausible that both genetic and epigenetic effects play roles in these differences. In addition, gender-specific lifestyle and behavioural factors may modulate the effects of exposure to genotoxins. This commentary focuses on several aspects of gender-related differences in responses to mutagens and carcinogens, including sensitivity to chromosome damage, the contribution of genotypic variation and the role of DNA methylation. It is concluded that the reasons for gender differences in cancer susceptibility remain largely unknown in many cases, and the subject deserves more attention and study.en
dc.description.sponsorshipM. K.-V., A. H., L. M. and D. H. P. are members of the European Union Network of Excellence Environmental Cancer Risk, Nutrition and Individual Susceptibility (ECNIS, www.ecnis.org, Contract No. FOOD-CT-2005- 513943). This commentary is based on the proceedings of a symposium held at the ECNIS Annual Meeting in Leuven, Belgium, in March 2009.en
dc.language.isoenen
dc.relation.urlhttp://mutage.oxfordjournals.org/content/25/3/213.longen
dc.subjectCarcinogensen
dc.subjectMutagensen
dc.subjectSmokingen
dc.subjectHumansen
dc.subjectChromosomesen
dc.subjectDNA Damageen
dc.subjectNeoplasmsen
dc.subjectSex Characteristicsen
dc.subject.meshCarcinogens-
dc.subject.meshChromosomes, Human, X-
dc.subject.meshChromosomes, Human, Y-
dc.subject.meshDNA Damage-
dc.subject.meshDNA Methylation-
dc.subject.meshFemale-
dc.subject.meshGenetic Predisposition to Disease-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMutagens-
dc.subject.meshNeoplasms-
dc.subject.meshSex Characteristics-
dc.subject.meshSmoking-
dc.titleGender-related differences in response to mutagens and carcinogens.en
dc.typeArticleen
dc.identifier.journalMutagenesisen

Related articles on PubMed

All Items in ECNIS-NIOM are protected by copyright, with all rights reserved, unless otherwise indicated.