Adherence to a Mediterranean diet and risk of gastric adenocarcinoma within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study.

2.50
Hdl Handle:
http://hdl.handle.net/10146/113461
Title:
Adherence to a Mediterranean diet and risk of gastric adenocarcinoma within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study.
Authors:
Buckland, Genevieve; Agudo, Antonio; Luján, Leila; Jakszyn, Paula; Bueno-de-Mesquita, H. Bas; Palli, Domenico; Boeing, Heiner; Carneiro, Fátima; Krogh, Vittorio; Sacerdote, Carlotta; Tumino, Rosario; Panico, Salvatore; Nesi, Gabriella; Manjer, Jonas; Regnér, Sara; Johansson, Ingegerd; Stenling, Roger; Sanchez, María-José; Dorronsoro, Miren; Barricarte, Aurelio; Navarro, Carmen; Quirós, J. Ramón; Allen, Naomi E.; Key, Timothy J.; Bingham, Sheila; Kaaks, Rudolf; Overvad, Kim; Jensen, Majken; Olsen, Anja; Tjønneland, Anne; Peeters, Petra H. M.; Numans, Mattijs E.; Ocké, Marga C.; Clavel-Chapelon, Françoise; Morois, Sophie; Boutron-Ruault, Marie-Christine; Trichopoulou, Antonia; Lagiou, Pagona; Trichopoulos, Dimitrios; Lund, Eiliv; Couto, Elisabeth; Boffeta, Paolo; Jenab, Mazda; Riboli, Elio; Romaguera, Dora; Mouw, Traci; González, Carlos A.
Abstract:
BACKGROUND: The Mediterranean dietary pattern is believed to protect against cancer, although evidence from cohort studies that have examined particular cancer sites is limited. OBJECTIVE: We aimed to explore the association between adherence to a relative Mediterranean diet (rMED) and incident gastric adenocarcinoma (GC) within the European Prospective Investigation into Cancer and Nutrition study. DESIGN: The study included 485,044 subjects (144,577 men) aged 35-70 y from 10 European countries. At recruitment, dietary and lifestyle information was collected. An 18-unit rMED score, incorporating 9 key components of the Mediterranean diet, was used to estimate rMED adherence. The association between rMED and GC with respect to anatomic location (cardia and noncardia) and histologic types (diffuse and intestinal) was investigated. A calibration study in a subsample was used to control for dietary measurement error. RESULTS: After a mean follow-up of 8.9 y, 449 validated incident GC cases were identified and used in the analysis. After stratification by center and age and adjustment for recognized cancer risk factors, high compared with low rMED adherence was associated with a significant reduction in GC risk (hazard ratio: 0.67; 95% CI: 0.47, 0.94). A 1-unit increase in the rMED score was associated with a decreased risk of GC of 5% (95% CI: 0.91, 0.99). There was no evidence of heterogeneity between different anatomic locations or histologic types. The calibrated results showed similar trends (overall hazard ratio for GC: 0.93; 95% CI: 0.89, 0.99). CONCLUSION: Greater adherence to an rMED is associated with a significant reduction in the risk of incident GC.
Citation:
Am. J. Clin. Nutr. 2010, 91 (2):381-390
Journal:
The American Journal of Clinical Nutrition
Issue Date:
Feb-2010
URI:
http://hdl.handle.net/10146/113461
DOI:
10.3945/ajcn.2009.28209
PubMed ID:
20007304
Additional Links:
http://www.ajcn.org/cgi/content/abstract/91/2/381
Type:
Article
Language:
en
ISSN:
1938-3207
Sponsors:
Some authors are partners of ECNIS, a network of excellence of the EC (6FP contract 513943).
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorBuckland, Genevieveen
dc.contributor.authorAgudo, Antonioen
dc.contributor.authorLuján, Leilaen
dc.contributor.authorJakszyn, Paulaen
dc.contributor.authorBueno-de-Mesquita, H. Basen
dc.contributor.authorPalli, Domenicoen
dc.contributor.authorBoeing, Heineren
dc.contributor.authorCarneiro, Fátimaen
dc.contributor.authorKrogh, Vittorioen
dc.contributor.authorSacerdote, Carlottaen
dc.contributor.authorTumino, Rosarioen
dc.contributor.authorPanico, Salvatoreen
dc.contributor.authorNesi, Gabriellaen
dc.contributor.authorManjer, Jonasen
dc.contributor.authorRegnér, Saraen
dc.contributor.authorJohansson, Ingegerden
dc.contributor.authorStenling, Rogeren
dc.contributor.authorSanchez, María-Joséen
dc.contributor.authorDorronsoro, Mirenen
dc.contributor.authorBarricarte, Aurelioen
dc.contributor.authorNavarro, Carmenen
dc.contributor.authorQuirós, J. Ramónen
dc.contributor.authorAllen, Naomi E.en
dc.contributor.authorKey, Timothy J.en
dc.contributor.authorBingham, Sheilaen
dc.contributor.authorKaaks, Rudolfen
dc.contributor.authorOvervad, Kimen
dc.contributor.authorJensen, Majkenen
dc.contributor.authorOlsen, Anjaen
dc.contributor.authorTjønneland, Anneen
dc.contributor.authorPeeters, Petra H. M.en
dc.contributor.authorNumans, Mattijs E.en
dc.contributor.authorOcké, Marga C.en
dc.contributor.authorClavel-Chapelon, Françoiseen
dc.contributor.authorMorois, Sophieen
dc.contributor.authorBoutron-Ruault, Marie-Christineen
dc.contributor.authorTrichopoulou, Antoniaen
dc.contributor.authorLagiou, Pagonaen
dc.contributor.authorTrichopoulos, Dimitriosen
dc.contributor.authorLund, Eiliven
dc.contributor.authorCouto, Elisabethen
dc.contributor.authorBoffeta, Paoloen
dc.contributor.authorJenab, Mazdaen
dc.contributor.authorRiboli, Elioen
dc.contributor.authorRomaguera, Doraen
dc.contributor.authorMouw, Tracien
dc.contributor.authorGonzález, Carlos A.en
dc.date.accessioned2010-10-19T11:20:19Z-
dc.date.available2010-10-19T11:20:19Z-
dc.date.issued2010-02-
dc.identifier.citationAm. J. Clin. Nutr. 2010, 91 (2):381-390en
dc.identifier.issn1938-3207-
dc.identifier.pmid20007304-
dc.identifier.doi10.3945/ajcn.2009.28209-
dc.identifier.urihttp://hdl.handle.net/10146/113461-
dc.description.abstractBACKGROUND: The Mediterranean dietary pattern is believed to protect against cancer, although evidence from cohort studies that have examined particular cancer sites is limited. OBJECTIVE: We aimed to explore the association between adherence to a relative Mediterranean diet (rMED) and incident gastric adenocarcinoma (GC) within the European Prospective Investigation into Cancer and Nutrition study. DESIGN: The study included 485,044 subjects (144,577 men) aged 35-70 y from 10 European countries. At recruitment, dietary and lifestyle information was collected. An 18-unit rMED score, incorporating 9 key components of the Mediterranean diet, was used to estimate rMED adherence. The association between rMED and GC with respect to anatomic location (cardia and noncardia) and histologic types (diffuse and intestinal) was investigated. A calibration study in a subsample was used to control for dietary measurement error. RESULTS: After a mean follow-up of 8.9 y, 449 validated incident GC cases were identified and used in the analysis. After stratification by center and age and adjustment for recognized cancer risk factors, high compared with low rMED adherence was associated with a significant reduction in GC risk (hazard ratio: 0.67; 95% CI: 0.47, 0.94). A 1-unit increase in the rMED score was associated with a decreased risk of GC of 5% (95% CI: 0.91, 0.99). There was no evidence of heterogeneity between different anatomic locations or histologic types. The calibrated results showed similar trends (overall hazard ratio for GC: 0.93; 95% CI: 0.89, 0.99). CONCLUSION: Greater adherence to an rMED is associated with a significant reduction in the risk of incident GC.en
dc.description.sponsorshipSome authors are partners of ECNIS, a network of excellence of the EC (6FP contract 513943).en
dc.language.isoenen
dc.relation.urlhttp://www.ajcn.org/cgi/content/abstract/91/2/381en
dc.subjectAdenocarcinomaen
dc.subjectStomach Neoplasmsen
dc.subjectprevention & controlen
dc.subjectDiet, Mediterraneanen
dc.subjectEurope/epidemiologyen
dc.subjectCohort Studiesen
dc.subject.meshAdenocarcinoma-
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshCohort Studies-
dc.subject.meshDiet, Mediterranean-
dc.subject.meshEurope-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshProportional Hazards Models-
dc.subject.meshProspective Studies-
dc.subject.meshQuestionnaires-
dc.subject.meshStomach Neoplasms-
dc.titleAdherence to a Mediterranean diet and risk of gastric adenocarcinoma within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study.en
dc.typeArticleen
dc.identifier.journalThe American Journal of Clinical Nutritionen

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